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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 5
1997 5
1998 10
1999 8
2000 11
2001 5
2002 19
2003 15
2004 21
2005 21
2006 17
2007 24
2008 24
2009 23
2010 22
2011 29
2012 27
2013 30
2014 35
2015 46
2016 41
2017 38
2018 31
2019 46
2020 44
2021 54
2022 52
2023 48
2024 27

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692 results

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Page 1
Neuroprotective Effect of SGLT2 Inhibitors.
Pawlos A, Broncel M, Woźniak E, Gorzelak-Pabiś P. Pawlos A, et al. Molecules. 2021 Nov 28;26(23):7213. doi: 10.3390/molecules26237213. Molecules. 2021. PMID: 34885795 Free PMC article. Review.
Flozins are not fully SGLT2-selective and have an affinity for the SGLT1 receptor, which is associated with protection against ischemia/reperfusion brain damage. SGLT2i show an anti-inflammatory and anti-atherosclerotic effect, including reduction of proinflammatory cytoki …
Flozins are not fully SGLT2-selective and have an affinity for the SGLT1 receptor, which is associated with protection against ischemia/repe …
Use of STAT1 inhibitors in the treatment of brain I/R injury and neurodegenerative diseases.
Ebner FH, Mariotto S, Darra E, Suzuki H, Cavalieri E. Ebner FH, et al. Cent Nerv Syst Agents Med Chem. 2011 Mar 1;11(1):2-7. doi: 10.2174/187152411794961077. Cent Nerv Syst Agents Med Chem. 2011. PMID: 20812906 Review.
John's wort, attenuates β-cell death induced by interferon-γ (IFN-γ) by strongly down-regulating STAT1 activation. STAT1, therefore, seems to represent a new molecular target of the protective treatment also against brain injury a …
John's wort, attenuates β-cell death induced by interferon-γ (IFN-γ) by strongly down-regulating STAT1 a …
Transcriptional regulation of macrophage polarization: enabling diversity with identity.
Lawrence T, Natoli G. Lawrence T, et al. Nat Rev Immunol. 2011 Oct 25;11(11):750-61. doi: 10.1038/nri3088. Nat Rev Immunol. 2011. PMID: 22025054 Review.
In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression program …
In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident mac …
Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-kappaB pathway dependent of HDAC3.
Chen S, Ye J, Chen X, Shi J, Wu W, Lin W, Lin W, Li Y, Fu H, Li S. Chen S, et al. J Neuroinflammation. 2018 May 18;15(1):150. doi: 10.1186/s12974-018-1193-6. J Neuroinflammation. 2018. PMID: 29776446 Free PMC article.
Immunofluorescent staining and Western blot analysis were used to detect HDAC3 nuclear translocation, activity, and NF-kappaB signaling pathway activation to evaluate the effects of VPA treatment. The impact of STAT1 acetylation on NF-kB pathway and the interaction between …
Immunofluorescent staining and Western blot analysis were used to detect HDAC3 nuclear translocation, activity, and NF-kappaB signaling path …
STAT1 Contributes to Microglial/Macrophage Inflammation and Neurological Dysfunction in a Mouse Model of Traumatic Brain Injury.
Zhao Y, Ma C, Chen C, Li S, Wang Y, Yang T, Stetler RA, Bennett MVL, Dixon CE, Chen J, Shi Y. Zhao Y, et al. J Neurosci. 2022 Sep 28;42(39):7466-7481. doi: 10.1523/JNEUROSCI.0682-22.2022. J Neurosci. 2022. PMID: 35985835 Free PMC article.
TBI induced robust upregulation of STAT1 in the brain at the subacute injury stage, which occurred primarily in Mi/Mphi. ...We also show excellent efficacy of a selective STAT1 inhibitor fludarabine against TBI-induced functional deficits and brain inj …
TBI induced robust upregulation of STAT1 in the brain at the subacute injury stage, which occurred primarily in Mi/Mphi. ...We …
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.
Chen Q, Boire A, Jin X, Valiente M, Er EE, Lopez-Soto A, Jacob L, Patwa R, Shah H, Xu K, Cross JR, Massagué J. Chen Q, et al. Nature. 2016 May 26;533(7604):493-498. doi: 10.1038/nature18268. Epub 2016 May 18. Nature. 2016. PMID: 27225120 Free PMC article.
Here we define the role of the most abundant cell type in the brain, the astrocyte, in promoting brain metastasis. We show that human and mouse breast and lung cancer cells express protocadherin 7 (PCDH7), which promotes the assembly of carcinoma-astrocyte gap junct …
Here we define the role of the most abundant cell type in the brain, the astrocyte, in promoting brain metastasis. We show tha …
Tetramethylpyrazine promotes axonal remodeling and modulates microglial polarization via JAK2-STAT1/3 and GSK3-NFkappaB pathways in ischemic stroke.
Feng X, Li M, Lin Z, Lu Y, Zhuang Y, Lei J, Liu X, Zhao H. Feng X, et al. Neurochem Int. 2023 Nov;170:105607. doi: 10.1016/j.neuint.2023.105607. Epub 2023 Aug 30. Neurochem Int. 2023. PMID: 37657766 Free article.
This study aims to evaluate whether TMP promotes the renovation of damaged brain tissues especially on remyelination and modulates microglia phenotypes following ischemic stroke. ...Then we demonstrate that TMP reverses M1/M2 phenotype via JAK2-STAT1/3 and GSK3-NFka …
This study aims to evaluate whether TMP promotes the renovation of damaged brain tissues especially on remyelination and modulates mi …
MBD5 regulates NMDA receptor expression and seizures by inhibiting Stat1 transcription.
Tang FL, Zhang XG, Ke PY, Liu J, Zhang ZJ, Hu DM, Gu J, Zhang H, Guo HK, Zang QW, Huang R, Ma YL, Kwan P. Tang FL, et al. Neurobiol Dis. 2023 Jun 1;181:106103. doi: 10.1016/j.nbd.2023.106103. Epub 2023 Mar 29. Neurobiol Dis. 2023. PMID: 36997128 Free article.
The epileptic behavioural phenotype was alleviated by overexpression of STAT1 which reduced the expression of NMDARs, and by the NMDAR antagonist memantine. These results indicate that MBD5 accumulation affects seizures through STAT1-mediated inhibition of NMDAR exp …
The epileptic behavioural phenotype was alleviated by overexpression of STAT1 which reduced the expression of NMDARs, and by the NMDA …
Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-kappaB and STAT1 pathway.
Ran Y, Qie S, Gao F, Ding Z, Yang S, Tian G, Liu Z, Xi J. Ran Y, et al. Brain Res. 2021 Nov 1;1770:147626. doi: 10.1016/j.brainres.2021.147626. Epub 2021 Aug 19. Brain Res. 2021. PMID: 34418356

Baicalein also inhibited the phosphorylation of signal transducer and activator of transcription 1 (STAT1, p < 0.001). A microglia-neuron co-culture system revealed that baicalein driven neuroprotection against OGD induced neuronal damage through modulating microglial p

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Baicalein also inhibited the phosphorylation of signal transducer and activator of transcription 1 (STAT1, p < 0.001). A microglia

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STAT1 drives M1 microglia activation and neuroinflammation under hypoxia.
Butturini E, Boriero D, Carcereri de Prati A, Mariotto S. Butturini E, et al. Arch Biochem Biophys. 2019 Jul 15;669:22-30. doi: 10.1016/j.abb.2019.05.011. Epub 2019 May 20. Arch Biochem Biophys. 2019. PMID: 31121156
In this paper we analyse the cellular mechanisms that drive M1 microglia activation in BV2 cells in response to hypoxia correlating it to STAT1 activation. The analysis of the molecular mechanism of STAT1 signaling reveals that hypoxia generates oxidative stress and …
In this paper we analyse the cellular mechanisms that drive M1 microglia activation in BV2 cells in response to hypoxia correlating it to …
692 results